반응 #68424

ord-9ea5ec2fa1d94314a853327d647639a1

반응 방정식

CC(C)c1c(C(=O)O)c2cc(F)c([N+](=O)[O-])cc2n1Cc1ccccc1
1-benzyl-5-fluoro-2-isopropyl-6-nitro-1H-indole-3-carboxylic acid
CC(C)c1c(C(=O)O)c2cc(F)c([N+](=O)[O-])cc2n1Cc1ccccc1
Compound 170
CC(C)c1c(C(=O)O)c2cc(F)c([N+](=O)[O-])cc2n1Cc1ccccc1
1-benzyl-5-fluoro-2-isopropyl-6-nitro-1H-indole-3-carboxylic acid
NCc1ccc(F)c(F)c1
3,4-difluorobenzylamine
→
CC(C)c1c(C(=O)NCc2ccc(F)c(F)c2)c2cc(F)c([N+](=O)[O-])cc2n1Cc1ccccc1
title compound
CC(C)c1c(C(=O)NCc2ccc(F)c(F)c2)c2cc(F)c([N+](=O)[O-])cc2n1Cc1ccccc1
1-Benzyl-N-(3,4-difluorobenzyl)-5-fluoro-2-isopropyl-6-nitro-1H-indole-3-carboxamide

반응물

CC(C)c1c(C(=O)O)c2cc(F)c([N+](=O)[O-])cc2n1Cc1ccccc1
1-benzyl-5-fluoro-2-isopropyl-6-nitro-1H-indole-3-carboxylic acid
CC(C)c1c(C(=O)O)c2cc(F)c([N+](=O)[O-])cc2n1Cc1ccccc1
Compound 170
CC(C)c1c(C(=O)O)c2cc(F)c([N+](=O)[O-])cc2n1Cc1ccccc1
1-benzyl-5-fluoro-2-isopropyl-6-nitro-1H-indole-3-carboxylic acid
NCc1ccc(F)c(F)c1
3,4-difluorobenzylamine

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

The title compound was prepared from 1-benzyl-5-fluoro-2-isopropyl-6-nitro-1H-indole-3-carboxylic acid (Compound 170) and 3,4-difluorobenzylamine by General Procedure C.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08524917B2uspto-grants-2013_09