반응 #68423
ord-b69f89d9b609410b9caa665553412561
반응 방정식
반응물
시약
없음
반응 조건
온도
80°CELSIUS
상세 조건
See reaction.notes.procedure_details.
후처리
- 1세척washed with brine
- 2건조dried over Na2SO4
- 3농축concentrated in vacuo
- 4기타The residue was purified by chromatography on silica gel (0→50% EtOAc-hexanes)
실험 절차
General Procedure Z. To a solution of ethyl1-benzyl-5-fluoro-2-isopropyl-6-nitro-1H-indole-3-carboxylate (Compound 169, 546 mg, 1.54 mmol) in EtOH (10 ml) was added 5 M NaOH (3.1 ml, 15.5 mmol). The reaction was heated at 80° C. for 5 h, diluted with EtOAc, washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by chromatography on silica gel (0→50% EtOAc-hexanes) to yield the title compound as a brown solid.