반응 #6841

반응 방정식

potassium cyanide

(5-methoxy-4-methyl-1H-indol-3-ylmethyl)dimethylamine

→

(5-methoxy-4-methyl-1H-indol-3-yl)-acetonitrile

수율 87.2%

용매

water

N,N-dimethylformamide

반응 조건

후처리

1. 1
   온도The solution was heated
2. 2
   온도to reflux for 40 min
3. 3
   추출The aqueous layer was extracted with three portions of toluene
4. 4
   세척the combined toluene layers were washed with water and brine
5. 5
   기타The solvent was removed in vacuo
6. 6
   기타the product purified by column chromatography dichloromethane) as the mobile phase

실험 절차

To a solution of potassium cyanide (0.74 g) in 20 mL water was added a solution of (5-methoxy-4-methyl-1H-indol-3-ylmethyl)dimethylamine (0.5 g) in 20 mL of N,N-dimethylformamide. The solution was heated to reflux for 40 min, cooled to rt, and 40 mL of ice water was added. The aqueous layer was extracted with three portions of toluene, and the combined toluene layers were washed with water and brine. The solvent was removed in vacuo and the product purified by column chromatography dichloromethane) as the mobile phase to yield (5-methoxy-4-methyl-1H-indol-3-yl)-acetonitrile (0.40 g).

출처