반응 #68398
ord-113939e042ae437eb830e7b09358bc95
반응 방정식
용매
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1workup.STIRRINGstirred for 1 h at 0° C. and 2 h at room temperature
- 2세척washed with H2O and brine
- 3건조dried over Na2SO4
- 4농축concentrated in vacuo
- 5기타The residue was purified by chromatography on silica gel (0→50% EtOAc-hexanes)
실험 절차
POCl3 (0.12 ml, 1.4 mmol) was added dropwise to anhydrous DMF (1.5 ml) at 0° C. under argon. After stirred for 20 min, a solution of 2-isopropyl-6-nitro-1H-indole (Compound 120, 115 mg, 0.56 mmol) in anhydrous DMF (1.5 ml) was added slowly to the above reaction and stirred for 1 h at 0° C. and 2 h at room temperature. The reaction was diluted with EtOAc, washed with H2O and brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by chromatography on silica gel (0→50% EtOAc-hexanes) to yield the title compound.