반응 #68344
ord-e260a3a3d007425aa909bffd6ed3e178
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반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1추출The reaction mixture was extracted with EtOAc (×3)
- 2세척the combined organic layer was washed with brine
- 3건조dried over Na2SO4
- 4농축concentrated in vacuo
- 5기타The residue was purified by chromatography on silica gel (0→50% EtOAc-hexanes)
실험 절차
Following General Procedure D, ethyl3-formyl-2-isopropyl-1-(pyridin-2-ylmethyl)-1H-indole-6-carboxylate (Compound 36, 287 mg, 0.82 mmol) in t-BuOH (6 ml), 2-methyl-2-butene (2.29 ml) was added a solution of NaH2PO4 (1.97 g, 16.4mmol) and NaClO2 (80%, 1.48 g, 16.4 mmol) in H2O (6 ml). The mixture was stirred at room temperature for 12 h. The reaction mixture was extracted with EtOAc (×3) and the combined organic layer was washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by chromatography on silica gel (0→50% EtOAc-hexanes) to yield the title compound as a light yellow solid.