반응 #6834

반응 방정식

Diisobutylaluminum hydride

2-(6-methoxy-1H-indol-3-yl)ethylamine

→

3-(2-amino-ethyl)-1H-indol-6-ol

수율 68.2%

용매

toluene

반응 조건

후처리

1. 1
   온도The resulting clear solution was refluxed for 10 h
2. 2
   기타quenched by the careful addition of 20 mL of 1:1 methyl alcohol
3. 3
   여과filtered
4. 4
   기타to remove the precipitated aluminum salts
5. 5
   기타The solvent was evaporated

실험 절차

Diisobutylaluminum hydride (1 M in toluene, 15 mL) was slowly added to a suspension of 2-(6-methoxy-1H-indol-3-yl)ethylamine (250 mg) in 20 mL of toluene. The resulting clear solution was refluxed for 10 h, then cooled to 0° C. and quenched by the careful addition of 20 mL of 1:1 methyl alcohol:water. The mixture was stirred for 15 min at rt and filtered to remove the precipitated aluminum salts. The solvent was evaporated to yield 158 mg of 3-(2-amino-ethyl)-1H-indol-6-ol.

출처