반응 #683389

반응 방정식

diethyl 2-tert-butoxycarbonyloxyiminomalonate

L-isoleucine

sodium hydroxide

→

N-tert-butoxycarbonyl-L-isoleucine

수율 103.7%

용매

tert-butyl alcohol

반응 조건

후처리

1. 1
   기타tert-Butyl alcohol was removed from the reaction mixture under reduced pressure and water
2. 2
   workup.ADDITIONwas added to the residue
3. 3
   세척The mixture was washed with ether
4. 4
   추출extracted with ethyl acetate
5. 5
   세척The extract was washed with water
6. 6
   기타dried
7. 7
   농축concentrated

실험 절차

A solution of diethyl 2-tert-butoxycarbonyloxyiminomalonate (1.9 g.) in tert-butyl alcohol (5 ml.) was added to a solution of L-isoleucine (656 mg.) in a 1N sodium hydroxide aqueous solution (5.0 ml.), and the mixture was stirred for 3 hours at room temperature. tert-Butyl alcohol was removed from the reaction mixture under reduced pressure and water was added to the residue. The mixture was washed with ether, adjusted to pH 3 with a 5% citric acid aqueous solution and extracted with ethyl acetate. The extract was washed with water, dried and concentrated to give N-tert-butoxycarbonyl-L-isoleucine (1.2 g.), oil.

출처