반응 #6832

반응 방정식

3-(4-methoxy-phenyl)acrylic acid ethyl ester

tetramethyl-guanidine

nitromethane

→

3-(4-methoxyphenyl)-4-nitrobutyric acid ethyl ester

반응 조건

후처리

1. 1
   기타The solvent was evaporated
2. 2
   기타the resulting residue was partitioned in 50 mL 1 N hydrochloric acid
3. 3
   기타The ethyl ether phase was collected
4. 4
   세척washed with 50 mL 1 N hydrochloric acid
5. 5
   건조The ether phase was dried over sodium sulfate
6. 6
   기타the solvent was evaporated

실험 절차

A solution of 3-(4-methoxy-phenyl)acrylic acid ethyl ester (1.0 g) and tetramethyl-guanidine (125 μL) was stirred for 24 h at 70° C. in 2.5 mL nitromethane. The solvent was evaporated and the resulting residue was partitioned in 50 mL 1 N hydrochloric acid and 50 mL ethyl ether. The ethyl ether phase was collected and washed with 50 mL 1 N hydrochloric acid. The ether phase was dried over sodium sulfate and the solvent was evaporated to furnish 1.15 g of 3-(4-methoxyphenyl)-4-nitrobutyric acid ethyl ester.

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