반응 #68309

반응 방정식

2-(1-benzyl-6-methoxy-1H-indol-2-yl)propan-2-ol

Compound 3

2-(1-benzyl-6-methoxy-1H-indol-2-yl)propan-2-ol

HCl Et2O

→

crude title compound

1-Benzyl-2-isopropyl-6-methoxy-1H-indole

용매

EtOAc

EtOH

반응 조건

후처리

1. 1
   여과was filtered
2. 2
   workup.ADDITIONTo the filtrate was added NaHCO3 (0.5 g) and H2O (0.5 ml)
3. 3
   여과This was then filtered
4. 4
   농축concentrated in vacuo

실험 절차

To a solution of 2-(1-benzyl-6-methoxy-1H-indol-2-yl)propan-2-ol (Compound 3, 1.05 g, 3.57 mmol) in EtOAc (35 ml) and EtOH (15 ml) was added 10% Pd—C (190 mg, 0.18 mmol) and HCl-Et2O (1.0 M, 1.25 ml, 1.25 mmol). The mixture was stirred under hydrogen gas (atmospheric pressure) for 1 h and was filtered. To the filtrate was added NaHCO3 (0.5 g) and H2O (0.5 ml), followed by Na2SO4 and MgSO4. This was then filtered and concentrated in vacuo to yield the crude title compound as a yellow solid.

출처