반응 #6822
ord-2e6609cbcbab46a8a867933955519b54
반응 방정식
2-(3-chloro-4-hydroxy-phenyl)-acetamide
imidazole
tert-butyldimethylsilyl chloride
→
2-[4-(tert-butyldimethylsilanyloxy)-3-chlorophenyl]acetamide
수율 77.4%
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1세척washed with 50 mL of sodium carbonate
- 2기타The ethyl acetate was evaporated
실험 절차
A solution of 2-(3-chloro-4-hydroxy-phenyl)-acetamide (100 mg), imidazole (184 mg), and tert-butyldimethylsilyl chloride (163 mg) was stirred for 2 h in 5 mL of dimethylformamide. The solution was diluted with 50 mL of ethyl acetate and washed with 50 mL of sodium carbonate. The ethyl acetate was evaporated to afford 125 mg of 2-[4-(tert-butyldimethylsilanyloxy)-3-chlorophenyl]acetamide.