반응 #681860

반응 방정식

2,3-dihydrobenzo[b][1,4]dioxine-5-carbaldehyde

(4-(trifluoromethoxy)phenyl)methanamine

→

rac-(3R*,5S*)-5-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-3-hydroxy-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one

반응 조건

후처리

1. 1
   기타Prepared
2. 2
   기타Subsequent purification by preparative HPLC
3. 3
   기타afforded the target compound

실험 절차

Prepared according to the described general procedures 10A2 (GP10A2), 10B (GP10B) and 10F (GP10F) using commercially available (4-(trifluoromethoxy)phenyl)methanamine and commercially available 2,3-dihydrobenzo[b][1,4]dioxine-5-carbaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.79 min.; [M+H]+: 409.94 g/mol.

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