반응 #68181

반응 방정식

1-(1,3-dioxolan-2-ylmethyl)-6-bromoquinolin-2(1H)-one

sodium hydrogen carbonate

→

(6-bromo-2-oxoquinolin-1(2H)-yl)acetaldehyde

용매

trifluoroacetic acid

반응 조건

후처리

1. 1
   추출was extracted with ethyl acetate
2. 2
   세척The organic layer was washed with aqueous saturated sodium chloride solution
3. 3
   건조dried over anhydrous magnesium sulfate
4. 4
   기타the solvent was removed under reduced pressure

실험 절차

0.56 g of 1-(1,3-dioxolan-2-ylmethyl)-6-bromoquinolin-2(1H)-one was dissolved in 4.5 mL of 67% aqueous trifluoroacetic acid solution, and stirred at room temperature for 18.5 hours, at 40° C. for 7.5 hours, further at room temperature for 15 hours. After the reaction mixture was alkalized by adding aqueous saturated sodium hydrogen carbonate solution, it was extracted with ethyl acetate. The organic layer was washed with aqueous saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to give (6-bromo-2-oxoquinolin-1(2H)-yl)acetaldehyde as a pale yellow solid.

출처