반응 #681561

반응 방정식

Water

5-(bromomethyl)-2-methylbenzo[d]oxazole

phthalimide potassium salt

→

2-((2-methylbenzo[d]oxazol-5-yl)methyl)isoindoline-1,3-dione

용매

DMF

반응 조건

후처리

1. 1
   여과the resulting precipitate was collected by filtration
2. 2
   세척washed with water
3. 3
   기타Drying under HV

실험 절차

A solution of 5-(bromomethyl)-2-methylbenzo[d]oxazole (400 mg; 1.76 mmol) in anh. DMF (2 ml) was treated portionwise with phthalimide potassium salt (327 mg; 1.76 mmol), and the resulting mixture was stirred at rt, under nitrogen, for 18 h. Water was added, and the resulting precipitate was collected by filtration, and washed with water. Drying under HV afforded 2-((2-methylbenzo[d]oxazol-5-yl)methyl)isoindoline-1,3-dione as a brown solid. LC-MS (conditions E): tR=0.66 min.; [M+H]+: 293.15 g/mol.

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