반응 #68104

반응 방정식

trifluoroacetic acid

1-(1,3-dioxolan-2-ylmethyl)-5-methoxyquinolin-2(1H)-one

→

(5-methoxy-2-oxoquinolin-1(2H)-yl)acetaldehyde

반응 조건

후처리

1. 1
   기타The solvent was removed under reduced pressure, ethyl acetate and water
2. 2
   workup.ADDITIONwere added
3. 3
   기타the organic layer was separated
4. 4
   workup.ADDITIONsodium chloride was added to the aqueous layer
5. 5
   추출extracted twice with ethyl acetate
6. 6
   세척washed with aqueous saturated sodium chloride solution
7. 7
   건조dried over anhydrous magnesium sulfate
8. 8
   기타the solvent was removed under reduced pressure

실험 절차

To 15 mL of 80% aqueous trifluoroacetic acid solution, 0.44 g of 1-(1,3-dioxolan-2-ylmethyl)-5-methoxyquinolin-2(1H)-one was added, and stirred at room temperature for 5 hours. The solvent was removed under reduced pressure, ethyl acetate and water were added, the organic layer was separated, and sodium chloride was added to the aqueous layer, and extracted twice with ethyl acetate. The organic layer and extracts were combined, washed with aqueous saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to give (5-methoxy-2-oxoquinolin-1(2H)-yl)acetaldehyde as a pale brown solid.

출처