반응 #68070

반응 방정식

ethanol

ethyl 4-(3-(2-oxoquinoxalin-1(2H)-yl)propyl)-1-(2-(2-thienylthio)ethyl)piperidine-4-carboxylate

sodium hydroxide

sodium hydroxide

→

4-(3-(2-oxoquinoxaline-1(2H)-yl)propyl)-1-(2-(2-thienylthio)ethyl)piperidine-4-carboxylic acid

수율 41.3%

용매

water

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   workup.STIRRINGstirred at 55-60° C. for 1 hour
3. 3
   온도The mixture was cooled to the room temperature
4. 4
   workup.WAITleft
5. 5
   workup.WAITto stand for 2 nights
6. 6
   기타The solvent was removed under reduced pressure, water
7. 7
   workup.ADDITIONwas added
8. 8
   workup.ADDITIONwas added
9. 9
   기타the solvent was removed under reduced pressure
10. 10
    workup.ADDITIONWater was added
11. 11
    여과the resulting solid was filtered

실험 절차

To 2 mL of an ethanol solution containing 90 mg of ethyl 4-(3-(2-oxoquinoxalin-1(2H)-yl)propyl)-1-(2-(2-thienylthio)ethyl)piperidine-4-carboxylate, 0.5 mL of 20% aqueous sodium hydroxide solution was added and stirred at 55-60° C. for 5 hours. 0.5 mL of 20% aqueous sodium hydroxide solution and 0.5 mL of water were added at the same temperature, and stirred at 55-60° C. for 1 hour. The mixture was cooled to the room temperature, and left to stand for 2 nights. The solvent was removed under reduced pressure, water was added, adjusted to pH 6.5 with 6.0 mol/L hydrochloric acid, acetonitrile was added, and the solvent was removed under reduced pressure. Water was added, and the resulting solid was filtered to afford 35 mg of 4-(3-(2-oxoquinoxaline-1(2H)-yl)propyl)-1-(2-(2-thienylthio)ethyl)piperidine-4-carboxylic acid as a brown solid.

출처