반응 #67986

반응 방정식

8-(2-(benzyloxy)ethyl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile

→

8-(2-hydroxyethyl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile

용매

ethanol

반응 조건

후처리

1. 1
   workup.ADDITIONwas added at room temperature
2. 2
   여과The insoluble material filtered off
3. 3
   기타the solvent was removed under reduced pressure

실험 절차

To 10 mL of an ethanol solution containing 1.0 g of 8-(2-(benzyloxy)ethyl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile, 0.50 g of 10% palladium-carbon was added at room temperature, and the mixture was stirred at 40 to 45° C. for 1 hour and 30 minutes under a hydrogen atmosphere. The insoluble material filtered off, and the solvent was removed under reduced pressure to obtained 0.80 g of a colorless oily substance, 8-(2-hydroxyethyl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile.

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