반응 #67978

반응 방정식

tert-butyl 4-(((benzyloxy)carbonyl)amino)-4-(hydroxymethyl)piperidine-1-carboxylate

→

tert-butyl 4-amino-4-(hydroxymethyl)piperidine-1-carboxylate

용매

ethanol

반응 조건

후처리

1. 1
   workup.ADDITIONwas added at room temperature
2. 2
   여과The insoluble material filtered off
3. 3
   기타the filtration residue thus obtained
4. 4
   세척was washed 3 times with chloroform
5. 5
   기타the solvent was removed under reduced pressure

실험 절차

To 10 mL of an ethanol solution containing 0.55 g of tert-butyl 4-(((benzyloxy)carbonyl)amino)-4-(hydroxymethyl)piperidine-1-carboxylate, 0.10 g of 20% palladium hydroxide-carbon was added at room temperature, and the mixture was stirred at 40° C. for 3 hours under a hydrogen atmosphere. The insoluble material filtered off, and the filtration residue thus obtained was washed 3 times with chloroform. The filtrate and the washing solution were combined, and the solvent was removed under reduced pressure to obtain 0.39 g of a dark brown oily substance, tert-butyl 4-amino-4-(hydroxymethyl)piperidine-1-carboxylate.

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