반응 #67976

반응 방정식

sodium hydroxide

7-(cyclopropoxy)-1-(1,3-dioxolan-2-ylmethyl)-4-methylquinolin-2(1H)-one

trifluoroacetic acid

sodium hydrogen carbonate

→

(7-(cyclopropoxy)-4-methyl-2-oxo-1,2-dihydroquinolin-1-yl)acetaldehyde

용매

water

ethyl acetate

반응 조건

후처리

1. 1
   workup.WAITstood still at room temperature for 14 hours
2. 2
   기타The organic layer was separated
3. 3
   세척washed sequentially with water
4. 4
   건조an aqueous saturated sodium chloride solution and dried over anhydrous magnesium sulfate
5. 5
   기타the solvent was removed under reduced pressure

실험 절차

To 95 mg of 7-(cyclopropoxy)-1-(1,3-dioxolan-2-ylmethyl)-4-methylquinolin-2(1H)-one, 1.5 mL of an 80% aqueous trifluoroacetic acid solution was added, the mixture was stirred at room temperature for 6 hours, and then stood still at room temperature for 14 hours. Thereto were added ethyl acetate and water, and the mixture was neutralized with an aqueous saturated sodium hydrogen carbonate solution and an aqueous sodium hydroxide solution. The organic layer was separated, washed sequentially with water and an aqueous saturated sodium chloride solution and dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to obtain 84 mg of a yellow oily substance, (7-(cyclopropoxy)-4-methyl-2-oxo-1,2-dihydroquinolin-1-yl)acetaldehyde.

출처