반응 #67968

반응 방정식

1-(1,3-dioxolan-2-ylmethyl)quinolin-2(1H)-one

trifluoroacetic acid

→

(2-oxoquinolin-1(2H)-yl)acetaldehyde

수율 77.2%

반응 조건

후처리

1. 1
   기타The solvent was removed under reduced pressure
2. 2
   workup.ADDITIONwere added an aqueous saturated sodium hydrogen carbonate solution and ethyl acetate
3. 3
   workup.STIRRINGthe mixture was stirred at room temperature for 30 minutes
4. 4
   기타The organic layer was separated
5. 5
   추출the aqueous layer was extracted 5 times with ethyl acetate
6. 6
   건조the resultant solution was dried over anhydrous magnesium sulfate
7. 7
   기타the solvent was removed under reduced pressure

실험 절차

To 0.88 g of 1-(1,3-dioxolan-2-ylmethyl)quinolin-2(1H)-one, 8.8 mL of a 90% aqueous trifluoroacetic acid solution was added, and the mixture was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure, thereto were added an aqueous saturated sodium hydrogen carbonate solution and ethyl acetate, and the mixture was stirred at room temperature for 30 minutes. The organic layer was separated, and the aqueous layer was extracted 5 times with ethyl acetate. The organic layer and an extract were combined, the resultant solution was dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to obtain 0.55 g of (2-oxoquinolin-1(2H)-yl)acetaldehyde.

출처