반응 #6792

반응 방정식

water

2-(methylsulfonyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidine

tetrahydro-2H-pyran-4-amine

→

title compound

수율 40.0%

4-[4-(methylsulfonyl)phenyl]-N-tetrahydro-2H-pyran-4-yl-6-(trifluoromethyl)pyrimidin-2-amine

수율 40.0%

용매

N-methylpyrrolidone

반응 조건

후처리

1. 1
   기타This resulted in a precipitate
2. 2
   기타being formed
3. 3
   여과which was collected by filtration
4. 4
   기타dried in vacuo (0.258 g)
5. 5
   기타This material was then purified by autopurification

실험 절차

To a solution of 2-(methylsulfonyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidine (0.277 g, 0.73 mmol) in N-methylpyrrolidone (1.25 ml) was added tetrahydro-2H-pyran-4-amine (0.147 g, 2 eq.), the mixture was stirred for 1 hour and then water (1.25 ml) was added dropwise. This resulted in a precipitate being formed, which was collected by filtration, and dried in vacuo (0.258 g). This material was then purified by autopurification to give the title compound as a colourless solid (0.116 g, 40%).

출처