반응 #67841

ord-e6241be8e6814e7788abe4ffbf422c69

반응 방정식

O=C(O)c1ccncc1Nc1ccc(I)cc1F
3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid
O=C(O)c1ccncc1Nc1ccc(I)cc1F
intermediate 1
O=C(O)c1ccncc1Nc1ccc(I)cc1F
3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid
NC1CCCCC1
cyclohexylamine
O=C(NC1CCCCC1)c1ccncc1Nc1ccc(I)cc1F
N-cyclohexyl-3-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타LC/MS [10.52 min; 440 (M+1)]

실험 절차

N-cyclohexyl-3-[(2-fluoro-4-iodophenyl)amino]isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.33 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.42 mmol of cyclohexylamine. LC/MS [10.52 min; 440 (M+1)]

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08524911B2uspto-grants-2013_09