반응 #6782

반응 방정식

4-carboxyindole

2-chloro-1-methylpyridinium iodide

4-phenethylpiperazine

ethyldi-isopropylamine

→

(1H-indol-4-yl)-(4-phenethylpiperazin-1-yl)methanone, hydrochloride

수율 100.1%

용매

acetone

N-methylpyrrolidone

NMP

반응 조건

후처리

1. 1
   기타the crude product is obtained
2. 2
   기타the hydrochloride is precipitated
3. 3
   기타After drying

실험 절차

A solution of 2.0 g of 4-carboxyindole and 8.1 g of 2-chloro-1-methylpyridinium iodide in 60 ml of N-methylpyrrolidone (NMP) is treated with a solution of 2.36 g of 4-phenethylpiperazine and 8.2 g of ethyldi-isopropylamine (EDIPA) in 20 ml of NMP and subsequently stirred at room temperature for 3 hours. The mixture is worked up in the customary manner and the crude product is obtained. This is dissolved in acetone and the hydrochloride is precipitated using aqueous hydrochloric acid. After drying, 4.59 g of (1H-indol-4-yl)-(4-phenethylpiperazin-1-yl)methanone, hydrochloride, m.p. 289.3°, is obtained.

출처