반응 #678084

반응 방정식

1,5-bis-(2-ethylhexyloxy)-2,6-dibromonaphthalene

tetrahydrofuran

n-butyl lithium

DMF

→

title compound

수율 45.0%

1,5-bis-(2-ethyl hexyloxy)naphthalene-2,6-dicarbaldehyde

수율 45.0%

반응 조건

후처리

1. 1
   workup.WAITfor 10 minutes
2. 2
   workup.STIRRINGfurther stirred for 30 minutes
3. 3
   온도After a temperature was raised to room temperature
4. 4
   workup.STIRRINGthe reactant was stirred for 1 hour
5. 5
   기타the reaction was terminated
6. 6
   온도by cool water
7. 7
   추출the resultant was extracted with ethylacetate
8. 8
   workup.DISTILLATIONfollowed by distillation under reduced pressure and column chromatography

실험 절차

After 1.0 g of 1,5-bis-(2-ethylhexyloxy)-2,6-dibromonaphthalene (1.8 mmol) was dissolved in 20 mL of tetrahydrofuran (THF), a temperature was raised to −78° C., and n-butyl lithium was slowly added thereto for 30 minutes. The mixture was stirred at −78° C. for 2 hours, and then 0.46 g of DMF (6.3 mmol) was slowly added thereto for 10 minutes and further stirred for 30 minutes. After a temperature was raised to room temperature and the reactant was stirred for 1 hour, the reaction was terminated by cool water, and the resultant was extracted with ethylacetate, followed by distillation under reduced pressure and column chromatography, thereby obtaining 1.1 g of the title compound (45.0%).

출처