반응 #67741

ord-a8df642aec964432aebaccffd2f0aeb7

반응 방정식

COc1ccc(Cc2cccc(NC(=O)C3(c4ccc5c(c4)OCO5)CC3)n2)cc1
1-(benzo[d][1,3]dioxol-5-yl)-N-(6-(4-methoxybenzyl)pyridin-2-yl)cyclopropanecarboxamide
Clc1ccccc1[CH2][Zn+].[Cl-]
(2-chlorobenzyl)zinc(II) chloride
O=C(Nc1cccc(Br)n1)C1(c2ccc3c(c2)OCO3)CC1
1-(benzo[d][1,3]dioxol-5-yl)-N-(6-bromopyridin-2-yl)cyclopropanecarboxamide
→
O=C(Nc1cccc(Cc2ccccc2Cl)n1)C1(c2ccc3c(c2)OCO3)CC1
1-(Benzo[d][1,3]dioxol-5-yl)-N-(6-(2-chlorobenzyl)pyridin-2-yl)cyclopropanecarboxamide

반응물

COc1ccc(Cc2cccc(NC(=O)C3(c4ccc5c(c4)OCO5)CC3)n2)cc1
1-(benzo[d][1,3]dioxol-5-yl)-N-(6-(4-methoxybenzyl)pyridin-2-yl)cyclopropanecarboxamide
Clc1ccccc1[CH2][Zn+].[Cl-]
(2-chlorobenzyl)zinc(II) chloride
O=C(Nc1cccc(Br)n1)C1(c2ccc3c(c2)OCO3)CC1
1-(benzo[d][1,3]dioxol-5-yl)-N-(6-bromopyridin-2-yl)cyclopropanecarboxamide

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

1-(Benzo[d][1,3]dioxol-5-yl)-N-(6-(2-chlorobenzyl)pyridin-2-yl)cyclopropanecarboxamide was synthesized using the procedure of 1-(benzo[d][1,3]dioxol-5-yl)-N-(6-(4-methoxybenzyl)pyridin-2-yl)cyclopropanecarboxamide by reacting (2-chlorobenzyl)zinc(II) chloride with 1-(benzo[d][1,3]dioxol-5-yl)-N-(6-bromopyridin-2-yl)cyclopropanecarboxamide.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08524910B2uspto-grants-2013_09