반응 #67736

ord-7e641642d7ed44c3b83621a8d86e4bd7

반응 방정식

O=C(Nc1cccc(Br)n1)C1(c2ccc3c(c2)OCO3)CC1
1-(benzo[d][1,3]dioxol-5-yl)-N-(6-bromopyridin-2-yl)cyclopropanecarboxamide
CC(C)[CH2][Zn+].[Cl-]
isobutylzinc(II) chloride
O=C(Nc1cccc(CC2CCCCC2)n1)C1(c2ccc3c(c2)OCO3)CC1
1-(benzo[d][1,3]dioxol-5-yl)-N-(6-(cyclohexylmethyl)pyridin-2-yl)cyclopropanecarboxamide
→
CC(C)Cc1cccc(NC(=O)C2(c3ccc4c(c3)OCO4)CC2)n1
1-(Benzo[d][1,3]dioxol-5-yl)-N-(6-isobutylpyridin-2-yl)cyclopropanecarboxamide

반응물

O=C(Nc1cccc(Br)n1)C1(c2ccc3c(c2)OCO3)CC1
1-(benzo[d][1,3]dioxol-5-yl)-N-(6-bromopyridin-2-yl)cyclopropanecarboxamide
CC(C)[CH2][Zn+].[Cl-]
isobutylzinc(II) chloride
O=C(Nc1cccc(CC2CCCCC2)n1)C1(c2ccc3c(c2)OCO3)CC1
1-(benzo[d][1,3]dioxol-5-yl)-N-(6-(cyclohexylmethyl)pyridin-2-yl)cyclopropanecarboxamide

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

1-(Benzo[d][1,3]dioxol-5-yl)-N-(6-isobutylpyridin-2-yl)cyclopropanecarboxamide was prepared from 1-(benzo[d][1,3]dioxol-5-yl)-N-(6-bromopyridin-2-yl)cyclopropanecarboxamide and isobutylzinc(II) chloride in a manner analogous to that of 1-(benzo[d][1,3]dioxol-5-yl)-N-(6-(cyclohexylmethyl)pyridin-2-yl)cyclopropanecarboxamide.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08524910B2uspto-grants-2013_09