반응 #67731

반응 방정식

tert-Butyl 3-(3-methylpyridin-4-yl)benzoate

hydrogen peroxide

→

4-(3-(tert-Butoxycarbonyl)phenyl)-3-methylpyridine 1-oxide

용매

dichloromethane

반응 조건

후처리

1. 1
   기타The layers were then separated
2. 2
   workup.ADDITIONthe organic layer was treated with sodium sulfite
3. 3
   건조dried over sodium sulfate
4. 4
   여과The crude product filtered
5. 5
   기타evaporated to dryness
6. 6
   기타used without further purification

실험 절차

tert-Butyl 3-(3-methylpyridin-4-yl)benzoate (0.500 g, 1.86 mmol) was dissolved in a mixture of dichloromethane (0.800 mL) and 30% hydrogen peroxide (0.421 mL). Methyltrioxorhenium (VII) (2.3 mg, 0.92 mmol) was added and the reaction mixture was stirred vigorously for 5 hours. The layers were then separated and the organic layer was treated with sodium sulfite, and then dried over sodium sulfate. The crude product filtered, evaporated to dryness, and used without further purification. ESI-MS m/z calc. 285.1. found 286.1 (M+1)+. Retention time 1.22 minutes.

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