반응 #67724

반응 방정식

Sodium hydroxide

2,2-difluoro-benzo[1,3]dioxol-5-yl-acetonitrile

benzyltriethylammonium

chloride

1-bromo-2-chloroethane

→

1-(2,2-difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonitrile

용매

water

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate
2. 2
   건조The combined organic layers were dried over sodium sulfate
3. 3
   기타evaporated to dryness

실험 절차

Sodium hydroxide (50% aqueous solution, 10 mL) was slowly added to a mixture of crude (2,2-difluoro-benzo[1,3]dioxol-5-yl-acetonitrile, benzyltriethylammonium, chloride (3.00 g, 15.3 mmol), and 1-bromo-2-chloroethane (4.9 g, 38 mmol) at 70° C. The mixture was stirred overnight at 70° C. before the reaction mixture was diluted with water (30 mL) and extracted with ethyl acetate. The combined organic layers were dried over sodium sulfate and evaporated to dryness to give crude 1-(2,2-difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonitrile, which was used directly in the next step.

출처