반응 #676697

ord-cc6fb26de4ee4d668e6a7b28139b041a

반응 방정식

CN(C)c1ccc(C(=O)Cl)cc1
4-dimethylamino-benzoyl chloride
COC(=O)c1ccc(C(=O)Nc2cc(F)cc(Br)c2C)c(F)c1
Intermediate 34
COC(=O)c1ccc(C(=O)Nc2cc(F)cc(Br)c2C)c(F)c1
N-(3-Bromo-5-fluoro-2-methyl-phenyl)-3-fluoro-terephthalamic acid methyl ester
→
Cc1c(Br)cc(F)cc1NC(=O)c1ccc(N(C)C)cc1
Intermediate 46
Cc1c(Br)cc(F)cc1NC(=O)c1ccc(N(C)C)cc1
N-(3-Bromo-5-fluoro-2-methyl-phenyl)-4-dimethylamino-benzamide

반응물

CN(C)c1ccc(C(=O)Cl)cc1
4-dimethylamino-benzoyl chloride
COC(=O)c1ccc(C(=O)Nc2cc(F)cc(Br)c2C)c(F)c1
Intermediate 34
COC(=O)c1ccc(C(=O)Nc2cc(F)cc(Br)c2C)c(F)c1
N-(3-Bromo-5-fluoro-2-methyl-phenyl)-3-fluoro-terephthalamic acid methyl ester

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Intermediate 46 was prepared analogue to Intermediate 34 by replacing Intermediate 33 with 4-dimethylamino-benzoyl chloride.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US09233111B2uspto-grants-2016_01