반응 #676498

반응 방정식

(+)-pinanediol

2-methylpropylboronic acid

→

oil

수율 98.6%

2-(2-methylpropyl)-(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborole

수율 98.6%

용매

diethyl ether

반응 조건

후처리

1. 1
   건조The mixture was dried over anhydrous sodium sulfate
2. 2
   기타purified by column chromatography (Silica gel 230-400 mesh)
3. 3
   세척eluting with hexane:ethyl acetate 90:10 mixture

실험 절차

A mixture of (+)-pinanediol (23.9 g, 0.140 mol) and 2-methylpropylboronic acid (15 g, 0.147 mol) in diethyl ether (300 ml) was stirred at room temperature for 24 h. The mixture was dried over anhydrous sodium sulfate and purified by column chromatography (Silica gel 230-400 mesh), eluting with hexane:ethyl acetate 90:10 mixture. The product was obtained as a clear oil (32.6 g, 94% yield).

출처