반응 #6757

반응 방정식

4-[(4-ethylthiophenyl)methyl]-3-(β-D-glucopyranosyloxy)-5-methyl-1H-pyrazole

acetic acid

acetic anhydride

→

1-acetyl-4-[(4-ethylthiophenyl)methyl]-3-(β-D-glucopyranosyloxy)-5-methylpyrazole

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated under reduced pressure, and diethyl ether
2. 2
   workup.ADDITIONwas added to the residue
3. 3
   기타The resulting precipitated crystal
4. 4
   여과was collected by filtration

실험 절차

To a solution of 4-[(4-ethylthiophenyl)methyl]-3-(β-D-glucopyranosyloxy)-5-methyl-1H-pyrazole (0.41 g) in tetrahydrofuran (10 mL) were added acetic acid (0.11 mL) and acetic anhydride (0.18 mL), and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure, and diethyl ether was added to the residue. The resulting precipitated crystal was collected by filtration to give 1-acetyl-4-[(4-ethylthiophenyl)methyl]-3-(β-D-glucopyranosyloxy)-5-methylpyrazole (0.36 g).

출처