반응 #675670

반응 방정식

(R)-tert-butyl 5-(1-aminoethyl)thiophene-2-carboxylate hydrochloride

triethylamine

HATU

1-benzothiophene-2-carboxylic acid

→

(R)-tert-butyl 5-(1-(benzothiophene-2-carboxamido)ethyl)thiophene-2-carboxylate

용매

DCM

DCM

water

반응 조건

후처리

1. 1
   workup.STIRRINGThe mixture was stirred at rt for 16 h
2. 2
   기타After separation
3. 3
   추출the aqueous layer was extracted with DCM (2×3 mL)
4. 4
   기타The combined organic phases were evaporated to dryness

실험 절차

To a 2-dram vial was added triethylamine (0.156 mL, 1.12 mmol), HATU (0.106 g, 0.28 mmol), 1-benzothiophene-2-carboxylic acid (0.050 g, 0.28 mmol), and DCM (3 mL). The solution was stirred at rt for 30 min, then transferred to another 2-dram vial containing solid (R)-tert-butyl 5-(1-aminoethyl)thiophene-2-carboxylate hydrochloride. The mixture was stirred at rt for 16 h. To the reaction was then added DCM (3 mL) and water (1 mL). After separation, the aqueous layer was extracted with DCM (2×3 mL). The combined organic phases were evaporated to dryness to give (R)-tert-butyl 5-(1-(benzothiophene-2-carboxamido)ethyl)thiophene-2-carboxylate as a brown solid. LC-MS: (FA) ES+ 388.

출처