반응 #67502

반응 방정식

2-cyano-3-fluoro-benzenesulfonyl chloride

thiazolidine

→

2-fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   농축The reaction mixture is concentrated in vacuo
2. 2
   기타Purification by Flash chromatography (eluent: cyclohexane/ethyl acetate 1:1)
3. 3
   세척by acidic washing with a 1M HCl solution

실험 절차

440 mg of 2-cyano-3-fluoro-benzenesulfonyl chloride in 10 ml of tetrahydrofuran are treated with 0.36 ml of thiazolidine and the mixture is stirred for 16 hours at room temperature. The reaction mixture is concentrated in vacuo. Purification by Flash chromatography (eluent: cyclohexane/ethyl acetate 1:1) followed by acidic washing with a 1M HCl solution affords 318 mg of 2-fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile.

출처