반응 #67501

반응 방정식

2-cyano-3-difluoromethoxy-benzenesulfonyl chloride

thiazolidine

→

2-difluoromethoxy-6-(thiazolidine-3-sulfonyl)-benzonitrile

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   농축The reaction mixture is concentrated in vacuo
2. 2
   기타Purification by HPLC

실험 절차

54 mg of 2-cyano-3-difluoromethoxy-benzenesulfonyl chloride in 10 ml of tetrahydrofuran are treated with 32 I of thiazolidine and the mixture is stirred for 16 hours at room temperature. The reaction mixture is concentrated in vacuo. Purification by HPLC affords 35 mg of 2-difluoromethoxy-6-(thiazolidine-3-sulfonyl)-benzonitrile.

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