반응 #67495

반응 방정식

Et3N

5-bromovaleric acid chloride

decahydroquinoline

AcOEt

→

4-bromo-1-(octahydroquinolin-1-yl)butan-1-one

반응 조건

후처리

1. 1
   세척The solution is then washed with water
2. 2
   추출the water re-extracted twice with AcOEt
3. 3
   세척The pooled organic phases are sequentially washed with 5% solution of NaHCO3, 1N HCl and saturated ammonium chloride solution
4. 4
   건조Finally the organic phase is dried over anhydrous Na2SO4, it
5. 5
   여과is filtered
6. 6
   기타the solvent is evaporated under reduced pressure
7. 7
   기타1.2 g of a yellow oil, which was used without subsequent purification
8. 8
   기타are obtained

실험 절차

1.37 mL (9.9 mmol) of Et3N and 0.5 mL (4.5 mmol) of 5-bromovaleric acid chloride are added to a solution of 1 mL (4.0 mmol) of the decahydroquinoline in AcOEt. The resulting solution is kept under stirring for 18 h at rt. The solution is then washed with water, and the water re-extracted twice with AcOEt. The pooled organic phases are sequentially washed with 5% solution of NaHCO3, 1N HCl and saturated ammonium chloride solution. Finally the organic phase is dried over anhydrous Na2SO4, it is filtered and the solvent is evaporated under reduced pressure. 1.2 g of a yellow oil, which was used without subsequent purification, are obtained.

출처