반응 #67488

반응 방정식

N-methylglutamic acid

sulfuric acid

→

N-methylglutamic acid sulfate

수율 97.8%

용매

water

반응 조건

후처리

1. 1
   기타for 30 minutes
2. 2
   workup.STIRRINGunder stirring
3. 3
   workup.STIRRINGstirred for additional 2 hours
4. 4
   기타After the reaction
5. 5
   농축the reaction solution was concentrated
6. 6
   기타azeotroped with toluene
7. 7
   기타to further remove the water
8. 8
   기타dried under vacuum

실험 절차

10.65 g of N-methylglutamic acid was placed in a 250 ml round-bottom flask, and 100 ml of water was added to the flask and stirred by using a magnetic stirrer for 30 minutes. Then, 6.38 g of concentrated sulfuric acid (concentration: 98%) was slowly dropped into the flask under stirring, and stirred for additional 2 hours after dropping. After the reaction, the reaction solution was concentrated, azeotroped with toluene to further remove the water and dried under vacuum to obtain 16.5 g of N-methylglutamic acid sulfate as yellow oil (Yield: 97.7%).

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