반응 #67428

반응 방정식

1-(benzo[d][1,3]dioxol-5-yl)-cyclopropanecarboxylic acid

CH2Cl2

thionyl chloride

→

1-Benzo[1,3]dioxol-5-yl-cyclopropanecarbonyl chloride

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   기타(2-3 h)
2. 2
   기타The excess thionyl chloride was removed under vacuum
3. 3
   workup.DISSOLUTIONthe resulting residue dissolved in CH2Cl2 (3 mL)

실험 절차

To an oven-dried round bottom flask containing 1-(benzo[d][1,3]dioxol-5-yl)-cyclopropanecarboxylic acid (A-8) (618 mg, 3.0 mmol) and CH2Cl2 (3 mL) was added thionyl chloride (1.07 g, 9.0 mmol) and N,N-dimethylformamide (0.1 mL). The reaction mixture was stirred at ambient temperature under an Ar atmosphere until the gas evolution ceased (2-3 h). The excess thionyl chloride was removed under vacuum and the resulting residue dissolved in CH2Cl2 (3 mL). The mixture was used without further manipulation.

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