반응 #67285

반응 방정식

[(2S)-7-bromo-5-fluoro-2,3-dihydro-1,4-benzodioxin-2-yl]methanol

sodium methanesulfinate

L-proline

NaOH

→

[(2S)-5-FLUORO-7-(METHYLSULFONYL)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL]METHANOL

용매

DMSO

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후처리

1. 1
   기타Preparation

실험 절차

Preparation according to Preparation 21 using [(2S)-7-bromo-5-fluoro-2,3-dihydro-1,4-benzodioxin-2-yl]methanol (2.35 g, 8.9 mmol), sodium methanesulfinate (85%) (1.29 g, 107 mmol), CuI (0.34 g, 1.8 mmol), L-proline (0.41 g, 3.6 mmol) and NaOH (0.071 g, 1.8 mmol) in DMSO (6 ml). Yield 0.98 g. MS m/z (rel. intensity, 70 eV) 262 (M+, bp), 231 (35), 183 (22), 152 (23), 57 (30).

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