반응 #67283

ord-667f8a43232045bcba8934513a35705c

용매

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타Preparation
  2. 2
    온도The mixture was heated
  3. 3
    온도at reflux for 24 h
  4. 4
    기타(Preparation 25)

실험 절차

Preparation according to Preparation 7 using 1-(5-bromo-3-fluoro-2-[(2R)-oxiran-2-ylmethoxyphenyl)ethanone (19.5 g, 67 mmol), CHCl3 and m-CPBA (77%, 60.5 g, 27 mmol). The mixture was heated at reflux for 24 h. The crude product was further used (Preparation 25). MS m/z (rel. intensity, 70 eV) 306 (M+, 4), 304 (M+, 4) 262 (bp), 69 (69), 57 (99).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08524766B2uspto-grants-2013_09