반응 #67265

반응 방정식

5-bromo-2-hydroxybenzaldehyde

(S)-glycidyltosylate

K2CO3

DMF

→

crude title compound

수율 107.6%

5-BROMO-2-[(2S)-OXIRAN-2-YLMETHOXY]BENZALDEHYDE

수율 107.6%

용매

Water

반응 조건

후처리

1. 1
   기타Preparation
2. 2
   추출the solution was extracted with EtOAc (3×100 ml)
3. 3
   세척The combined organic phases were washed with LiCl (5%, 100 ml), HCl (1 N, 100 ml), brine
4. 4
   기타were dried
5. 5
   농축concentrated

실험 절차

Preparation according to Preparation 1 using 5-bromo-2-hydroxybenzaldehyde (6 g, 30 mmol), (S)-glycidyltosylate (8.2 g, 36 mmol), K2CO3 (4.9 g, 36 mmol) and DMF (12 ml). Water (100 ml) was added and the solution was extracted with EtOAc (3×100 ml). The combined organic phases were washed with LiCl (5%, 100 ml), HCl (1 N, 100 ml), brine, were dried and concentrated to give the crude title compound (8.3 g). MS m/z (rel. intensity, 70 eV) 257 (M+, 38), 256 (M+, 39), 200 (bp), 199 (87), 57 (88).

출처