반응 #67229

ord-59c30031df5f4d46bc9ba5f5ae8d0c4d

반응 방정식

Cc1ccc(S(=O)(=O)OC[C@H]2COc3c(Cl)cc(S(C)(=O)=O)cc3O2)cc1
[(2R)-5-chloro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate
COCCN
2-methoxyethanamine
→
COCCNC[C@H]1COc2c(Cl)cc(S(C)(=O)=O)cc2O1
N-{[(2S)-5-CHLORO-7-(METHYLSULFONYL)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL]METHYL}-2-METHOXYETHANAMINE

반응물

Cc1ccc(S(=O)(=O)OC[C@H]2COc3c(Cl)cc(S(C)(=O)=O)cc3O2)cc1
[(2R)-5-chloro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate
—
( 8 )
—
( 18 )
—
( 8 )
—
( 12 )
COCCN
2-methoxyethanamine

시약

없음

용매

CC#N
ACN

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타Preparation

실험 절차

Preparation according to Example 57 using [(2R)-5-chloro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate (0.027 g, 0.062 mmol), 2-methoxyethanamine (0.5 ml), ACN (3 ml). MS m/z (rel. intensity, 70 eV) 335 (M+, 1), 290 (18), 88 (bp), 70 (8), 58 (8), 56 (12).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08524766B2uspto-grants-2013_09