반응 #67207

ord-81f3492a44754a83b9b8ffceea6e1305

반응 방정식

Cc1ccc(S(=O)(=O)OCC2COc3c(F)cc(S(C)(=O)=O)cc3O2)cc1
[5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl-4-methylbenzenesulfonate
CCCNCCC
N-propylpropan-1-amine
→
CCCN(CCC)CC1COc2c(F)cc(S(C)(=O)=O)cc2O1
N-{[5-FLUORO-7-(METHYLSULFONYL)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL]METHYL}-N-PROPYLPROPAN-1-AMINE

반응물

—
( 8 )
Cc1ccc(S(=O)(=O)OCC2COc3c(F)cc(S(C)(=O)=O)cc3O2)cc1
[5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl-4-methylbenzenesulfonate
CCCNCCC
N-propylpropan-1-amine
—
( 6 )
—
( 21 )

시약

없음

용매

CC#N
ACN

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타Preparation

실험 절차

Preparation according to Example 42 using [5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl-4-methylbenzenesulfonate (0.005 g, 0.012 mmol), N-propylpropan-1-amine (0.5 ml), ACN (2.5 ml). MS m/z (rel. intensity, 70 eV) 345 (M+, 0.5), 316 (21), 115 (8), 114 (bp), 112 (6).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08524766B2uspto-grants-2013_09