반응 #67205

ord-069e94dfc4db4438a2011f4b78497234

반응 방정식

Cc1ccc(S(=O)(=O)OCC2COc3c(F)cc(S(C)(=O)=O)cc3O2)cc1
[5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl-4-methylbenzenesulfonate
C1COCCN1
morpholine
→
CS(=O)(=O)c1cc(F)c2c(c1)OC(CN1CCOCC1)CO2
4-{[5-FLUORO-7-(METHYLSULFONYL)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL]METHYL}MORPHOLINE

반응물

—
( 4 )
Cc1ccc(S(=O)(=O)OCC2COc3c(F)cc(S(C)(=O)=O)cc3O2)cc1
[5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl-4-methylbenzenesulfonate
C1COCCN1
morpholine
—
( 5 )
—
( 5 )

시약

없음

용매

CC#N
ACN

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타Preparation

실험 절차

Preparation according to Example 42 using [5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl-4-methylbenzenesulfonate (0.005 g, 0.012 mmol), morpholine (0.5 ml), ACN (2.5 ml). MS m/z (rel. intensity, 70 eV) 331 (M+, 1), 101 (5), 100 (bp), 98 (4), 56 (5).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08524766B2uspto-grants-2013_09