반응 #671231

반응 방정식

CH3CN

1-(3-Chloro-5-trifluoromethyl-phenyl)-piperazine

K2CO3

CH3CN

→

title compound

1-(3-Chloro-5-trifluoromethyl-phenyl)-4-propyl-piperazine

반응 조건

후처리

1. 1
   여과The reaction mixture was filtered
2. 2
   기타the volatiles were evaporated in vacuum
3. 3
   기타The oily residue was chromatographed on a silica column with MeOH: CH2Cl2 (1:9 (v/v)) as eluent
4. 4
   기타Collection of the fractions
5. 5
   workup.ADDITIONcontaining pure
6. 6
   기타product and evaporation of the solvent

실험 절차

A suspension of 1-(3-Chloro-5-trifluoromethyl-phenyl)-piperazine (100 mg) and ground K2CO3 (200 mg) was stirred in CH3CN (30 mL) at room temperature. A solution of 1-bromo-propyl (52 mg) in CH3CN (5 mL) was added dropwise. The mixture was stirred at 50° C. overnight. The reaction mixture was filtered and the volatiles were evaporated in vacuum. The oily residue was chromatographed on a silica column with MeOH: CH2Cl2 (1:9 (v/v)) as eluent. Collection of the fractions containing pure product and evaporation of the solvent afforded the title compound (85 mg). MS m/z (relative intensity, 70 eV) 306 (M+, 25), 277 (bp), 234 (23), 206 (23), 179 (23).

출처