반응 #6710

반응 방정식

N-Methyl-piperidine-2-carboxylic acid ethyl ester

NaOH

hydrochloric acid

→

N-methyl-piperidine-2-carboxylic acid

용매

methanol

water

반응 조건

후처리

1. 1
   기타evaporated to dryness
2. 2
   기타evaporated four times with toluene

실험 절차

N-Methyl-piperidine-2-carboxylic acid ethyl ester (5.1 g) was dissolved in a mixture of 100 ml methanol and 10 ml water. NaOH (8 g) was added and the reaction mixture was stirred at room temperature overnight. The solution was then neutralized with hydrochloric acid, evaporated to dryness, and evaporated four times with toluene. The resulting powdery residue was used directly in the next step.

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