반응 #670341

반응 방정식

Acetyl-2-deoxy-2-fluoro-3,4,6-tri-O-benzyl-glucopyranose

Hydrazine acetate

→

2-deoxy-2-fluoro-3,4,6-tri-O-benzyl glucopyranose

수율 72.9%

용매

dichloromethane

DMF

반응 조건

후처리

1. 1
   세척the organic layer was washed with water (3×150 mL)
2. 2
   건조dried over sodium sulfate
3. 3
   여과filtered
4. 4
   기타evaporated

실험 절차

Acetyl-2-deoxy-2-fluoro-3,4,6-tri-O-benzyl-glucopyranose (750 mg) was dissolved in anhydrous DMF (7.5 mL). Hydrazine acetate (300 mg) was added and the reaction mixture was stirred for 3 hours at room temperature until most of the starting material was converted into product. The solution was diluted with dichloromethane (150 mL) and the organic layer was washed with water (3×150 mL), dried over sodium sulfate, filtered and evaporated. Chromatography of the material on silica gel using hexane-ethyl acetate (5:1) as eluent provided 2-deoxy-2-fluoro-3,4,6-tri-O-benzyl glucopyranose (500 mg).

출처