반응 #66952

반응 방정식

3-aminopyrazole

phthalic anhydride

→

title compound

수율 92.2%

2-(1H-pyrazol-3-yl)-1H-isoindole-1,3(2H)-dione

수율 92.2%

용매

1,4-dioxane

반응 조건

후처리

1. 1
   온도at reflux for 17 hours
2. 2
   기타to reach room temperature
3. 3
   기타solvent was evaporated to dryness
4. 4
   세척Residue was washed with EtOH
5. 5
   여과a yellowish solid was filtered

실험 절차

In a 500 mL round-bottom flask a mixture of 3-aminopyrazole (Aldrich, 10 g, 120 mmol) and phthalic anhydride (Aldrich, 24.96 g, 168 mmol) in 1,4-dioxane (150 mL) was stirred at reflux for 17 hours. The reaction was allowed to reach room temperature and solvent was evaporated to dryness. Residue was washed with EtOH and a yellowish solid was filtered to afford 23.6 g (yield 92%) of the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm: 13.09 (br s, 1H), 7.89-7.98 (m, 4H), 7.86 (br s, 1H), 6.36 (d, 1H). [ES+MS] m/z 214 (MH+).

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