반응 #66945

반응 방정식

hydrochloric acid

sodium hydroxide

3-ethoxy-4-hydroxybenzaldehyde

acetone

→

yellow crystal

수율 70.4%

4-(3-Ethoxy-4-hydroxyphenyl)-3-buten-2-one

수율 70.4%

용매

ethanol

water

반응 조건

후처리

1. 1
   여과the precipitated yellow solid was collected by filtration
2. 2
   세척washed with water and ethanol successively
3. 3
   기타dried
4. 4
   기타recrystallized from 95% ethanol

실험 절차

10% sodium hydroxide aqueous solution (80 ml) was added under stirring to a solution of 3-ethoxy-4-hydroxybenzaldehyde (16.6 g, 100 mmol) in acetone (50 ml), 95% ethanol (50 ml) and water (400 ml). The reaction mixture was stirred for 24 hr at room temperature, after the reaction completed, the reaction mixture was neutralized with 6N hydrochloric acid to adjust pH=7.0, the precipitated yellow solid was collected by filtration, washed with water and ethanol successively, dried, and then recrystallized from 95% ethanol to give 14.5 g of a yellow crystal, mp: 98-100° C., yield 70.4%.

출처