반응 #669384

반응 방정식

3-(4-methoxyphenyl)propionic acid

bromine

→

title compound

수율 87.0%

3-(3-Bromo-4-methoxyphenyl)propionic acid

수율 87.0%

용매

water

acetic acid

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate
2. 2
   세척The extract was washed serially with saturated saline and water
3. 3
   건조dried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure
5. 5
   세척The residue was washed with hexane

실험 절차

To a solution of 3-(4-methoxyphenyl)propionic acid (4.0 g, 22.2 mmol) in acetic acid (20 ml) was added bromine (3.9 g, 24.4 mmol) gradually dropwise at 10° C. and the mixture was stirred at room temperature for 30 minutes. This reaction mixture was diluted with water and extracted with ethyl acetate. The extract was washed serially with saturated saline and water and dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure. The residue was washed with hexane to provide the title compound (yield 5.0 g, 87%).

출처