반응 #669344

반응 방정식

E-3(1-trityl-1,2,4-triazol-5-yl)prop-2-en-1-ol

→

3(1-trityl-1,2,4-triazol-5-yl)propanol

수율 74.3%

용매

dichloromethane

반응 조건

후처리

1. 1
   여과The mixture was filtered through Hyflo Super-Cel
2. 2
   기타evaporated under reduced pressure
3. 3
   기타chromatographed

실험 절차

A stirred solution of E-3(1-trityl-1,2,4-triazol-5-yl)prop-2-en-1-ol (9.5 g, prepared as described in Example 9) in dichloromethane (100 ml) was hydrogenated over 5% palladium-carbon (50 mg) at room temperature and pressure for four hours. The mixture was filtered through Hyflo Super-Cel, evaporated under reduced pressure and chromatographed, using ethyl acetate-hexane (4:1), then ethyl acetate, as eluants, to give 3(1-trityl-1,2,4-triazol-5-yl)propanol (7.1 g, m.p. 150-152° C.). NMR (CDCl3): δ 1.4(2H,m), 2.2(2H,t), 3.45(2H,t), 7.1-7.3(15H,m), 7.9(1H,s).

출처