반응 #66893

반응 방정식

2,4-difluoro-5-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride

2,4-Difluoro-5-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride

(2E)-4-(dimethylamino)but-2-enoic acid hydrochloride

(2E)-4-(Dimethylamino)but-2-enoic acid hydrochloride

→

5-({7-[(2E)-4-(Dimethylamino)but-2-enoyl]-5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]-pyrimidin-4-yl}amino)-2,4-difluorophenol

반응 조건

후처리

1. 1
   기타to yield 40 mg (32%)

실험 절차

The compound was synthesized in analogy to Example 122 from 2,4-difluoro-5-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride from Example 71A (100 mg, 0.27 mmol) and (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride from Example 1A (63 mg, 0.38 mmol) to yield 40 mg (32%).

출처